Decubitus Treatment System

ABSTRACT

The present invention includes compositions and methods for cleaning, treating, protection and resolution of decubitus ulcers comprising: a first composition comprising a wound cleaning solution comprising aloe vera gel comprising at least 5,000 MPS, a balanced salt solution; and a second composition comprising a wound healing gel comprising aloe vera gel comprising at least 10,000 MPS, a thickening agent, and one or more preservatives and, optionally, a third composition comprising a moisture barrier cream comprising a vegetable-based emulsifier, a cosmetic ester for dry skin that has low occlusivity, an ester-based emollient that is oxidation stable and has low occlusivity; a beeswax; a hydrogenated oil, glycerin, a buffering agent, aloe vera gel comprising at least 2,000 MPS and water.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation patent application of U.S. patentapplication Ser. No. 14/579,190 filed on Dec. 22, 2014 and entitled“Decubitus Treatment System,” which is a continuation patent applicationof U.S. patent application Ser. No. 14/038,930 filed on Sep. 27, 2013and entitled “Decubitus Treatment System,” which claims priority to U.S.Provisional Application Ser. No. 61/708,965, filed Oct. 2, 2012, theentire contents of which are incorporated herein by reference.

TECHNICAL FIELD OF THE INVENTION

The present invention relates in general to the field of wound case, andmore particularly, to compositions, methods and kits for treatment andmaintenance of skin with or at-risk of decubitus ulcers.

STATEMENT OF FEDERALLY FUNDED RESEARCH

None.

BACKGROUND OF THE INVENTION

Without limiting the scope of the invention, its background is describedin connection with wound case, and more particularly, to the treatmentof decubitus ulcers.

One system for treating decubitus ulcers is taught in United StatesPatent Application Publication No. 2012/0116251, filed by Ben-Shalom, etal. entitled “System and Method For Preventing Decubitus Ulcers,” thatincludes a pressure detection mat comprising a plurality ofpressure-detection sensors. The mat is configured to be placed between asubject and a platform and to couple with a pressure-wound preventionsystem. The pressure wound prevention system is configured to receivedata from the sensors within pressure detection mats, process, interpretand analyze the data, and display the analyzed data to a user. Thispressure wound prevention system aims to assist in the prevention ofbedsores in immobilized patients, and may be particularly useful in homecare environments, acute care facilities, long term care facilities,hospices, hospitals, nursing homes, assisted living facilities and thelike.

Another method for treating decubitus ulcers is taught in United StatesPatent Application Publication No. 2008/0188546, filed by Takeda, et al.entitled “Preventive Or Therapeutic Agents For Decubitus,” that providesa preventive or preventing therapeutic agent for decubitus comprising anN-acylated derivative of hydroxyproline or a salt thereof; the abovepreventive or therapeutic agent wherein the N-acylated derivative ofhydroxyproline or a salt thereof is contained in an amount of 0.1 to 15%by weight to the total weight; and the preventive or therapeutic agentfor decubitus wherein the N-acylated group of the N-acylated derivativeof hydroxyproline is an N-acylated group having 1 to 24 carbon atoms.

Yet another method for treating decubitus ulcers is taught in UnitedStates Patent Application Publication No. 2006/0166885, filed by VanBekkum and Willem entitled “Treatment and Prevention of Decubitus,” thatincludes a method for treating a subject suffering from, or at risk ofsuffering from, decubitus, the method comprising a step of administeringerythropoietin (EPO), or a functional part, derivative or analoguethereof to the subject. In certain embodiments, the EPO has beenrecombinantly produced in host cells that further express the E1Aprotein of an adenovirus.

U.S. Pat. No. 7,655,717, issued to Goulbourne is entitled, “Ointmentcomposition for treating decubitus ulcers and methods for its making andits use” and teaches an ointment composition for treating decubitusulcers and methods for its making and its use. The composition includesa skin protestant ointment, a rash cream, an antibiotic ointment, virginolive oil, and boric acid powder. The skin protestant ointment includesactive ingredients petroleum 53.4%, lanolin 15.5%, and inactiveingredients cod liver oil containing vitamin A & vitamin D, a fragrance,light mineral oil, microcrystalline wax, and paraffin. The rash creamincludes active ingredients dimethicone 1% and zinc oxide 10%, andinactive ingredients aloe barbadensis extract, benzyl alcohol, coconutoil, cod liver oil containing vitamin A & vitamin D, a fragrance,glycerol oleate, light mineral oil, ozokerite, paraffin, propyleneglycol, sorbitol, synthetic beeswax, and water. The antibiotic ointmentincludes active ingredients polymyxin B sulfate 5,000 units, bacitracinzinc 400 units, and neomycin base (as sulfate) 3.5 mg., and an inactiveingredient white petroleum.

SUMMARY OF THE INVENTION

The present invention includes compositions, methods and kits fortreatment and maintenance of skin with or at-risk of decubitus ulcers.

More particularly, in one embodiment the present invention includes atwo-part composition for the cleaning, treatment, and resolution ofdecubitus ulcers comprising: a first composition comprising a woundcleaning solution comprising aloe vera gel comprising at least 5,000MPS, a balanced salt solution; and a second composition comprising awound healing gel comprising aloe vera gel comprising at least 10,000MPS, a thickening agent, and one or more preservatives. In one aspect,the composition further comprises a third composition comprising amoisture barrier cream comprising a vegetable-based emulsifier, acosmetic ester for dry skin that has low occlusivity, an ester-basedemollient that is oxidation stable and has low occlusivity; a beeswax; ahydrogenated oil, glycerin, a buffering agent, aloe vera gel comprisingat least 2,000 MPS and water. In another aspect, the balanced saltsolution comprises: NaCl, KCl, CaCl₂, NaHCO₃ and Na₂HPO₄ adjusted to pH4.5. In another aspect, the thickening agent comprises at least one ofxanthan gum, guar gum or locust bean gum. In another aspect, one or morepreservatives comprise benzoate salts, benzonium salts, or sorbatesalts. In another aspect, the vegetable based emulsifier comprises aDiisostearoyl Polyglyceryl-3 Dimer Dilinoleate, a Polyglyceryl-4Isostearate, a Polyglyceryl-4 Diisostearate, a Polyglyceryl-4Diisostearate/Polyhydroxystearate/Sebacate or a Polyglyceryl-3 Oleate.In another aspect, the cosmetic ester for dry skin that has lowocclusivity is cetearyl ethylhexanoate. In another aspect, theester-based emollient that is oxidation stable and has low occlusivityis isocetyl Palmitate. In another aspect, the hydrogenated oil ishydrogenated castor oil.

Another embodiment of the present invention includes a method ofcleaning and treating decubitus ulcers comprising: identifying a patientin need of treatment of one or more decubitus ulcers; cleaning the oneor more decubitus ulcers with a first composition comprising a woundcleaning solution comprising aloe vera gel comprising at least 5,000MPS, a balanced salt solution; and coating the one or more decubitusulcers with a second composition comprising a wound healing gelcomprising aloe vera gel comprising at least 10,000 MPS, a thickeningagent, and one or more preservatives. In one aspect, the inventionfurther comprising the step of providing the one or more decubitusulcers with a moisture barrier with a third composition comprising amoisture barrier cream comprising a vegetable-based emulsifier, acosmetic ester for dry skin that has low occlusivity, an ester-basedemollient that is oxidation stable and has low occlusivity; a beeswax; ahydrogenated castor oil, glycerin, a buffering agent, aloe vera gelcomprising at least 2,000 MPS and water. In another aspect, the balancedsalt solution comprises: NaCl, KCl, CaCl₂, NaHCO₃ and Na₂HPO₄ adjustedto pH 4.5. In another aspect, the thickening agent comprises at leastone of xanthan gum, guar gum or locust bean gum. In another aspect, theone or more preservatives comprise benzoate salts, benzonium salts, orsorbate salts. In another aspect, the vegetable based emulsifiercomprises a Diisostearoyl Polyglyceryl-3 Dimer Dilinoleate, aPolyglyceryl-4 Isostearate, a Polyglyceryl-4 Diisostearate, aPolyglyceryl-4 Diisostearate/Polyhydroxystearate/Sebacate or aPolyglyceryl-3 Oleate. In another aspect, the cosmetic ester for dryskin that has low occlusivity is cetearyl ethylhexanoate. In anotheraspect, the ester-based emollient that is oxidation stable and has lowocclusivity is isocetyl Palmitate. In another aspect, the hydrogenatedoil is hydrogenated castor oil.

Another embodiment of the present invention includes a three-partcomposition for the cleaning, treatment, and resolution of decubitusulcers comprising: a first composition comprising a wound cleaningsolution comprising aloe vera gel comprising at least 5,000 MPS, abalanced salt solution; and a second composition comprising a woundhealing gel comprising aloe vera gel comprising at least 10,000 MPS, athickening agent, and one or more preservatives; and a third compositioncomprising a moisture barrier cream comprising a vegetable-basedemulsifier, a cosmetic ester for dry skin that has low occlusivity, anester-based emollient that is oxidation stable and has low occlusivity;a beeswax; a hydrogenated castor oil, glycerin, a buffering agent, aloevera gel comprising at least 2,000 MPS and water. In one aspect, thebalanced salt solution comprises: NaCl, KCl, CaCl₂, NaHCO₃ and Na₂HPO₄adjusted to pH 4.5. In another aspect, the thickening agent comprises atleast one of xanthan gum, guar gum or locust bean gum. In anotheraspect, the one or more preservatives comprise benzoate salts, benzoniumsalts, or sorbate salts. In another aspect, the vegetable basedemulsifier comprises a Diisostearoyl Polyglyceryl-3 Dimer Dilinoleate, aPolyglyceryl-4 Isostearate, a Polyglyceryl-4 Diisostearate, aPolyglyceryl-4 Diisostearate/Polyhydroxystearate/Sebacate or aPolyglyceryl-3 Oleate. In another aspect, the cosmetic ester for dryskin that has low occlusivity is cetearyl ethylhexanoate. In anotheraspect, the ester-based emollient that is oxidation stable and has lowocclusivity is isocetyl Palmitate. In another aspect, the hydrogenatedoil is hydrogenated castor oil.

Another embodiment of the present invention includes a three-partcomposition for the cleaning, treatment, and resolution of decubitusulcers comprising: a first composition consisting essentially of a woundcleaning solution comprising aloe vera gel comprising at least 5,000MPS, a balanced salt solution; and a second composition consistingessentially of a wound healing gel comprising aloe vera gel comprisingat least 10,000 MPS, a thickening agent, and one or more preservatives;and a third composition consisting essentially of a moisture barriercream comprising a vegetable-based emulsifier, a cosmetic ester for dryskin that has low occlusivity, an ester-based emollient that isoxidation stable and has low occlusivity; a beeswax; a hydrogenatedcastor oil, glycerin, a buffering agent, aloe vera gel comprising atleast 2,000 MPS and water.

BRIEF DESCRIPTION OF THE DRAWINGS

For a more complete understanding of the features and advantages of thepresent invention, reference is now made to the detailed description ofthe invention along with the accompanying figures and in which:

FIGS. 1A-1C show the course of treatment of patient with decubitus forday 1 (FIG. 1A); day 20 (FIG. 1B) and day 30 (FIG. 1C);

FIGS. 2A-2C show the course of treatment of patient with decubitus forday 1 (FIG. 2A); day 7 (FIG. 2B) and day 14 (FIG. 2C); and

FIGS. 3A-3C show the course of treatment of patient with decubitus forday 1 (FIG. 3A); day 10 (FIG. 3B) and day 14 (FIG. 3C).

DETAILED DESCRIPTION OF THE INVENTION

While the making and using of various embodiments of the presentinvention are discussed in detail below, it should be appreciated thatthe present invention provides many applicable inventive concepts thatcan be embodied in a wide variety of specific contexts. The specificembodiments discussed herein are merely illustrative of specific ways tomake and use the invention and do not delimit the scope of theinvention.

To facilitate the understanding of this invention, a number of terms aredefined below. Terms defined herein have meanings as commonly understoodby a person of ordinary skill in the areas relevant to the presentinvention. Terms such as “a”, “an” and “the” are not intended to referto only a singular entity, but include the general class of which aspecific example may be used for illustration. The terminology herein isused to describe specific embodiments of the invention, but their usagedoes not delimit the invention, except as outlined in the claims.

As used herein, the term “aloe vera” followed by MPS (formucopolysaccharide) and a number (e.g., 2,000; 5,000 or 10,000) refersto a natural aloe vera gel product that has an average molecular weightdistribution for long-chain poly saccharides of 2,000 saccharidesmolecules per chain, 5,000 saccharides per chain, and 10,000 saccharidesper chain, respectively. The Aloe vera mucopolysaccharide (MPS) is along chain sugar molecule composed of individual mannose and glucosesugar molecules connected together. There is wide range in the size ofthe mucopolysaccharide molecule. Therefore, Aloe 2000 refers to acomposition in which the mucopolysaccharide molecules average 2,000saccharides per chain, which can be determined using, e.g., sizeexclusion chromatography and gel electrophoresis.

As used herein, the term “preservative” refers to a natural or syntheticsubstance that is added to the present invention to prevent the growth,or decomposition of, the composition by microbes or chemical changes tothe composition. Non-limiting examples of preservatives that may beoptionally used with the present invention include benzoic acid and itssalts, sorbic acid and its salts, calcium propionate, sodium nitrite,sodium nitrate, and sulfites (sulfur dioxide, sodium bisulfate,potassium hydrogen sulfite).

I. Wound-Wash 1. Aloe 5000 10.000% 2. Balanced Electrolyte Solution*89.98% 3. Citricidal 0.020% *Balanced Electrolyte Solution: 1. NaCl0.700% 2. KCl 0.040% 3. CaCl₂ (anhydrous)** 0.026% 4. NaHCO₃ 0.220% 5.Na₂HPO₄ (anhydrous)** 0.040% *Hydrated salt forms may be used withcorrection in quantity used. Adjust product to a final pH of 4.5 withphosphoric acid. Dispense: 4 oz. Spray Bottles II. Accelerin -Woundhealing Gel 1. Aloe Barbadensis Leaf Liquid (10,000 MPS) • 97.80% 2.Xanthan Gum: 2.00% 3. Potassium Sorbate: 0.10% 4. Sodium Benzoate: 0.10%Dispense: 2 oz Plastic Tubes with small orifice III. Moisture BarrierCream Phase A 1. ISOLAN PDI 3.00% 2. TEGOSOFT Liquid 9.500% 3. TEGOSFTHP 9.500% 4. Beeswax 0.600% 5. Hydrogenated Castor Oil 0.400% Phase B 1.Glycerin USP 3.000% 2. MgSO₄•7 H2O 1.000% 3. Purified Water 43.000% 4.Aloe 2,000 30.000% 5. Preservatives q.s. 6. Fragrance, if any (Apple,Cinnamon, Clove) q.s.

Preparation

1. Heat Phase A to 80 C and add Phase B (80 C or room temperature)slowly with constant stirring.2. Cool down and homogenize at 30 C.Other Additives: Extracts of green tea, Lavender, Calendula, Chamomile,Allantoin.Dispense: 2 oz Plastic tubes with small orifice.

IV. Post-Healing Skin Protectant

-   -   1. COATS Aloe Lotion/Cream: aloe vera gel, water, glycerin,        allantoin, panthenol, sodium hyalurate, excipients and        softeners, petrolatum, organic shea butter and preservatives (if        necessary).    -   2. Dimethicone 1% added to above.        Dispense: 4 OZ Plastic Tubes with small orifice.

Three patients were treated using the following Decubitus UlcerTreatment Protocol:

1. Determine the size and staging of the lesion. 2. Take a photograph ofthe lesion along with a small plastic: ruler for size determination. 3.Take a culture for the identification of micro-organisms and determinetheir pathogenic significance. 4. Irrigate the wound with normal saline.5. Apply Wound Wash to the wound and leave in place for five minutesafter which remove excess fluid with a sterile gauze sponge. 6. Apple agenerous amount of Accelerin (Aloe vera Gel) and cover with a sterile4×4 gauze sponge. 7. Apply Moisture Barrier to areas of potentialinvolvement, especially at night to prevent urine scalds. 8. Once woundresponds to the treatment protocol to a substantial degree take intervalphotographs. 9. Once wound is healed apply ter in die (t.i.d.) generousamounts of Aloe Protection Cream to vulnerable areas for possiblecutaneous breakdown. 10. Check potential wound areas frequently based onpatient's usual and favorite positions. FIGS. 1A-1C, 2A-2C, 3A-3C showthe results from using the compositions, methods and protocols of thepresent invention. Briefly, FIGS. 1A-1C show the course of treatment ofpatient with decubitus for day 1 (FIG. 1A); day 20 (FIG. 1B) and day 30(FIG. 1C). FIGS. 2A-2C show the course of treatment of patient withdecubitus for day 1 (FIG. 2A); day 7 (FIG. 2B) and day 14 (FIG. 2C).FIGS. 3A-3C show the course of treatment of patient with decubitus forday 1 (FIG. 3A); day 10 (FIG. 3B) and day 14 (FIG. 3C).

It is contemplated that any embodiment discussed in this specificationcan be implemented with respect to any method, kit, reagent, orcomposition of the invention, and vice versa. Furthermore, compositionsof the invention can be used to achieve methods of the invention.

It will be understood that particular embodiments described herein areshown by way of illustration and not as limitations of the invention.The principal features of this invention can be employed in variousembodiments without departing from the scope of the invention. Thoseskilled in the art will recognize, or be able to ascertain using no morethan routine experimentation, numerous equivalents to the specificprocedures described herein. Such equivalents are considered to bewithin the scope of this invention and are covered by the claims.

All publications and patent applications mentioned in the specificationare indicative of the level of skill of those skilled in the art towhich this invention pertains. All publications and patent applicationsare herein incorporated by reference to the same extent as if eachindividual publication or patent application was specifically andindividually indicated to be incorporated by reference.

The use of the word “a” or “an” when used in conjunction with the term“comprising” in the claims and/or the specification may mean “one,” butit is also consistent with the meaning of “one or more,” “at least one,”and “one or more than one.” The use of the term “or” in the claims isused to mean “and/or” unless explicitly indicated to refer toalternatives only or the alternatives are mutually exclusive, althoughthe disclosure supports a definition that refers to only alternativesand “and/or.” Throughout this application, the term “about” is used toindicate that a value includes the inherent variation of error for thedevice, the method being employed to determine the value, or thevariation that exists among the study subjects.

As used in this specification and claim(s), the words “comprising” (andany form of comprising, such as “comprise” and “comprises”), “having”(and any form of having, such as “have” and “has”), “including” (and anyform of including, such as “includes” and “include”) or “containing”(and any form of containing, such as “contains” and “contain”) areinclusive or open-ended and do not exclude additional, unrecitedelements or method steps.

The term “or combinations thereof” as used herein refers to allpermutations and combinations of the listed items preceding the term.For example, “A, B, C, or combinations thereof” is intended to includeat least one of: A, B, C, AB, AC, BC, or ABC, and if order is importantin a particular context, also BA, CA, CB, CBA, BCA, ACB, BAC, or CAB.Continuing with this example, expressly included are combinations thatcontain repeats of one or more item or term, such as BB, AAA, AB, BBC,AAABCCCC, CBBAAA, CABABB, and so forth. The skilled artisan willunderstand that typically there is no limit on the number of items orterms in any combination, unless otherwise apparent from the context.

As used herein, words of approximation such as, without limitation,“about”, “substantial” or “substantially” refers to a condition thatwhen so modified is understood to not necessarily be absolute or perfectbut would be considered close enough to those of ordinary skill in theart to warrant designating the condition as being present. The extent towhich the description may vary will depend on how great a change can beinstituted and still have one of ordinary skilled in the art recognizethe modified feature as still having the required characteristics andcapabilities of the unmodified feature. In general, but subject to thepreceding discussion, a numerical value herein that is modified by aword of approximation such as “about” may vary from the stated value byat least ±1, 2, 3, 4, 5, 6, 7, 10, 12 or 15%.

All of the compositions and/or methods disclosed and claimed herein canbe made and executed without undue experimentation in light of thepresent disclosure. While the compositions and methods of this inventionhave been described in terms of preferred embodiments, it will beapparent to those of skill in the art that variations may be applied tothe compositions and/or methods and in the steps or in the sequence ofsteps of the method described herein without departing from the concept,spirit and scope of the invention. All such similar substitutes andmodifications apparent to those skilled in the art are deemed to bewithin the spirit, scope and concept of the invention as defined by theappended claims.

REFERENCES

-   United States Patent Application Publication No. 2012/0116251-   United States Patent Application Publication No. 2008/0188546-   United States Patent Application Publication No. 2006/0166885-   U.S. Pat. No. 7,655,717

What is claimed is:
 1. A two-part composition for the cleaning,treatment, and resolution of decubitus ulcers comprising: a firstcomposition comprising a wound cleaning solution comprising aloe veragel comprising at least 5,000 MPS, a balanced salt solution; and asecond composition comprising a wound healing gel comprising aloe veragel comprising at least 10,000 MPS, a thickening agent, and one or morepreservatives.
 2. The composition of claim 1, wherein the compositionfurther comprises a third composition comprising a moisture barriercream comprising a vegetable-based emulsifier, a cosmetic ester for dryskin that has low occlusivity, an ester-based emollient that isoxidation stable and has low occlusivity; a beeswax; a hydrogenated oil,glycerin, a buffering agent, aloe vera gel comprising at least 2,000 MPSand water.
 3. The composition of claim 1, wherein the balanced saltsolution comprises: NaCl, KCl, CaCl₂, NaHCO₃ and Na₂HPO₄ adjusted to pH4.5.
 4. The composition of claim 1, wherein the thickening agentcomprises at least one of xanthan gum, guar gum or locust bean gum. 5.The composition of claim 1, wherein one or more preservatives comprisebenzoate salts, benzonium salts, or sorbate salts.
 6. The composition ofclaim 2, wherein the vegetable based emulsifier comprises aDiisostearoyl Polyglyceryl-3 Dimer Dilinoleate, a Polyglyceryl-4Isostearate, a Polyglyceryl-4 Diisostearate, a Polyglyceryl-4Diisostearate/Polyhydroxystearate/Sebacate or a Polyglyceryl-3 Oleate.7. The composition of claim 1, wherein the cosmetic ester for dry skinthat has low occlusivity is cetearyl ethylhexanoate.
 8. The compositionof claim 1, wherein the ester-based emollient that is oxidation stableand has low occlusivity is isocetyl Palmitate.
 9. The composition ofclaim 1, wherein the hydrogenated oil is hydrogenated castor oil.
 10. Amethod of cleaning and treating decubitus ulcers comprising: identifyinga patient in need of treatment of one or more decubitus ulcers; cleaningthe one or more decubitus ulcers with a first composition comprising awound cleaning solution comprising aloe vera gel comprising at least5,000 MPS, a balanced salt solution; and coating the one or moredecubitus ulcers with a second composition comprising a wound healinggel comprising aloe vera gel comprising at least 10,000 MPS, athickening agent, and one or more preservatives.
 11. A three-partcomposition for the cleaning, treatment, and resolution of decubitusulcers comprising: a first composition comprising a wound cleaningsolution comprising aloe vera gel comprising at least 5,000 MPS, abalanced salt solution; and a second composition comprising a woundhealing gel comprising aloe vera gel comprising at least 10,000 MPS, athickening agent, and one or more preservatives; and a third compositioncomprising a moisture barrier cream comprising a vegetable-basedemulsifier, a cosmetic ester for dry skin that has low occlusivity, anester-based emollient that is oxidation stable and has low occlusivity;a beeswax; a hydrogenated castor oil, glycerin, a buffering agent, aloevera gel comprising at least 2,000 MPS and water.
 12. The composition ofclaim 11, wherein the balanced salt solution comprises: NaCl, KCl,CaCl₂, NaHCO₃ and Na₂HPO₄ adjusted to pH 4.5.
 13. The composition ofclaim 11, wherein the thickening agent comprises at least one of xanthangum, guar gum or locust bean gum.
 14. The composition of claim 11,wherein one or more preservatives comprise benzoate salts, benzoniumsalts, or sorbate salts.
 15. The composition of claim 11, wherein thevegetable based emulsifier comprises a Diisostearoyl Polyglyceryl-3Dimer Dilinoleate, a Polyglyceryl-4 Isostearate, a Polyglyceryl-4Diisostearate, a Polyglyceryl-4Diisostearate/Polyhydroxystearate/Sebacate or a Polyglyceryl-3 Oleate.16. The composition of claim 11, wherein the cosmetic ester for dry skinthat has low occlusivity is cetearyl ethylhexanoate.
 17. The compositionof claim 11, wherein the ester-based emollient that is oxidation stableand has low occlusivity is isocetyl Palmitate.
 18. The composition ofclaim 11, wherein the hydrogenated oil is hydrogenated castor oil.
 19. Athree-part composition for the cleaning, treatment, and resolution ofdecubitus ulcers comprising: a first composition consisting essentiallyof a wound cleaning solution comprising aloe vera gel comprising atleast 5,000 MPS, a balanced salt solution; and a second compositionconsisting essentially of a wound healing gel comprising aloe vera gelcomprising at least 10,000 MPS, a thickening agent, and one or morepreservatives; and a third composition consisting essentially of amoisture barrier cream comprising a vegetable-based emulsifier, acosmetic ester for dry skin that has low occlusivity, an ester-basedemollient that is oxidation stable and has low occlusivity; a beeswax; ahydrogenated castor oil, glycerin, a buffering agent, aloe vera gelcomprising at least 2,000 MPS and water.